pots specialist mayo clinic

Because of this, providers often recommend eating several smaller meals throughout the day instead of two or three large ones. Emotions can have a significant influence on your daily life and health. Mayo Clinic, 200 First Street SW Phone: (507)284-3373 Dr. Pearl Jones. "Adolescent patients diagnosed with POTS may experience decreased school attendance, withdrawal from extracurricular activities, decreased academic performance and truancy," notes Dr. Driscoll. It's a form of dysautonomia. Majority of doctors fall within this rating. Superficial siderosis mimicking amyotrophic lateral sclerosis. Part 1 of the study will prospectively obtain the values of mast cell mediators, including 2,3 dinor 11-PGF2, n-MH, and LTE4 in the urine of a healthy pediatric reference population. "Education and motivating patients to incorporate new healthy-living practices into their lives can help remediate POTS symptoms and reduce the negative impact of POTS and chronic fatigue in adolescents," says Dr. Driscoll. Talk with your provider for specific instructions on these exercises. . It was developed at the Mayo Clinic, the Northwest Autonomic Laboratory and Clinic uses these protocols. 8188397101 . Sarah E. Berini, M.D. Brent P. Goodman, Deven H. Mistry, Shabana F. Pasha, Peter E. Bosch, Clinical and electrodiagnostic findings in copper deficiency myeloneuropathy, Brent P. Goodman, E P Bosch, Mark A. Ross, Charlene Hoffman-Snyder, D D Dodick, Benn E. Smith. After about 30 minutes of lying flat, the table is quickly tilted to raise your body to a head-up position simulating a change in position from lying down to standing up. Make sure the temperature is ideal in your bedroom to help you get proper rest. Vasculitic neuropathy following exposure to minocycline. In some patients, fatigue is due to a concurrent medical condition, inadequate sleep habits or coexisting psychological challenges. To improve the effective circulatory volume and enhance venous return, patients are advised to avoid sudden changes in posture, prolonged recumbency, high temperatures, large meals, and vasodilating or sympathomimetic drugs. GI Disorder and Internal Shaking. The study aims to evaluate if a hybrid semi-supervised remote monitoring three month strength and aerobic exercise training program can be as efficacious as in-person exercise training has previously demonstrated. Policy. This study is designed to investigate whether the treatment of non-anemic iron deficiency with intervenous iron sucrose will result in decreased symptom reporting and improved cardiovascular indices in adolescents (age 12-18) with Postural Orthostatic Tachycardia Syndrome (POTS). We hypothesize that as a non-fatal condition, a complete physiological profile of the POTS patients can be built entirely remotely therefore avoiding the need for these patients to visit the hospital and clinic. These symptoms may vary considerably from one person to another. Wear compression hose, not socks, 5grams at least of salt per day, electrolytes and plenty of water. The term POTS was coined by Mayo Clinic researchers in 1993. In the study by Mayo Clinic, there . Although postural tachycardia syndrome is a chronic condition, about 80 percent of patients grow out of it. This content does not have an Arabic version. For reasons not fully understood, many people who have POTS need up to three times more sodium than the standard limit recommended by the US Dietary Guidelines, which is 2,300 milligrams a day (roughly 1 teaspoon of salt). Adjusting droxidopa for neurogenic orthostatic hypotension in a patient with Parkinson disease. Christopher L. Kramer, Andrea J. Some general guidelines for preventing flare-ups include: The prognosis (outlook) for POTS is generally good, although it can severely disrupt daily living. Kizilbash SJ, et al. Compound muscle action potential duration in critical illness neuromyopathy. Also, check your blood pressure and pulse when you arent feeling well. I do have bowel movements every day but it takes a long time & I am rarely fully cleared out. The condition doesnt decrease life expectancy. They forced me to exercise. 1. Autonomic dysfunction in adult-onset alexander disease: a case report and review of the literature, Scott D. Spritzer, Srijana Zarkou, Stephen P. Ireland, Jonathon L. Carter, Brent P. Goodman. The purpose of this study is to evaluate if the patient/participant will self-enter clinical survey information into an iPad or choose to enter the same information by paper and pen for use in clinical research. Disrupted sleep from chest pain, racing heart rate and excessive sweating during sleep. Nonconvulsive status epilepticus secondary to acute porphyria crisis. She remembers it from medical school. My daughter kk er recently had cdif from antibiotics. Pace, Jonas Axelsson, Jeffrey R. Boris, Jeffrey P. Moak, Brent P. Goodman, Kamal R. Chmali, Tae H. Chung, David S. Goldstein, Andr Diedrich, Mitchell G. Miglis, Melissa M. Cortez, Amanda J. Miller, Roy Freeman, Italo Biaggioni, Peter C. Rowe, Robert S. Sheldon, Cyndya A. Shibao, David M. Systrom, Glen A. Cook, Taylor A. Doherty, Hasan I. Abdallah, Anil Darbari, Satish R. Raj, Standardized Autonomic Testing in Patients With Probable Radiation-Induced Afferent Baroreflex Failure, Brent P. Goodman, Julie Khoury, Janis E. Blair, Marie F. Grill. Lauren Manzo Scalia is sharing an exciting update on her physical and mental health. Approach to the evaluation of small fiber peripheral neuropathy and disorders of orthostatic intolerance. Other successes and current endeavors include: You may have the opportunity to participate in research studies and clinical trials as part of your treatment at Mayo Clinic. Your neurologist works with experts in other specialties, including neuroradiology, sleep medicine, speech pathology, and physical medicine and rehabilitation. Mayo Clinic is a not-for-profit organization. See all conditions on Dr. Goodman's. Medical compression stockings can also help push blood up from your legs to reduce POTS symptoms. It's a very stressful condition both physically and pyschologically as you know. If needed, part of the evaluation may include a pediatric neurologist, a pediatric gastroenterologist, a pediatric cardiologist or a pain specialist. Philip (Phil) R. Fischer, M.D., studies a variety of general pediatric issues. Details can be discussed at the time of appointment scheduling. Abby Feiner. Chronic fatigue is common and often multifactorial in adolescents. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Make a donation. This site complies with the HONcode standard for trustworthy health information: verify here. It's called the quantitative sudomotor axon reflex test (QSART). The mission of the Northwest Autonomic Lab and Clinics is: Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Until that happens, treatment can ease postural tachycardia syndrome symptoms. As a rehabilitation specialist, his goal in patient care is to restore function as close as possible to the baseline. Brent P. Goodman, M.D. Endocrinology, Diabetes & Metabolism. Standing frequently, such as when youre waiting in line or shopping. All rights reserved. If you have POTS, try to see a healthcare provider who specializes in POTS to get the best care. Although most people with POTS have healthy hearts, your provider may recommend a cardiac rehab program. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Postural orthostatic tachycardia syndrome (POTS) is a condition that causes your heart to beat faster than normal when you transition from sitting or lying down to standing up. But in 2021, Maya died at age . Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. A tilt table test is the main way providers diagnose POTS. Initiating droxidopa for neurogenic orthostatic hypotension in a patient with Parkinson disease. Radiation-induced cranial neuropathies manifesting as baroreflex failure and progressive bulbar impairment. This content does not have an English version. All of these medications have potential side effects. POTS has several possible symptoms, and they vary from person to person. People with serious signs and symptoms that affect their daily lives might be evaluated and treated by the doctors of the specialty group for autonomic neurology. Mayo Clinic pediatric and adolescent physician Philip Fischer, M.D., introduces a patient diagnosed with postural tachycardia syndrome, more commonly known as POTS. Learning that you have postural orthostatic tachycardia syndrome (POTS) can be overwhelming. Lots of research is going to be required to find out who the doctors are, whether they signed letters against PACE and . POTS-associated pain and fatigue symptoms, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. . After lying flat for a while, the table is tilted to a position that mimics standing. Erika Driver-Dunckley, Joseph M. Hoxworth, Naresh P. Patel, E. Peter Bosch, Brent P. Goodman. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Priya S. Dhawan, Brent P. Goodman, C. M. Harper, Peter E. Bosch, Charlene Hoffman-Snyder, Kay E. Wellik, Dean M. Wingerchuk, Bart M. Demaerschalk. Defining successful treatment of neurogenic orthostatic hypotension with droxidopa in a patient with multiple system atrophy. In a recent article published in Current Problems in Pediatric and Adolescent Health Care, Dr. Driscoll and colleagues provide an overview about POTS and chronic fatigue, reviewing the relevant medical and psychological literature, and drawing upon the authors' practice experiences. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Autonomic symptom burden is associated with MS-related fatigue and quality of life. Get enough sleep and eat well to help manage stress. In people who have postural tachycardia syndrome, the blood vessels are too relaxed. When these patients don't get relief from typical medical or nonpharmacologic strategies, they may benefit from a comprehensive rehabilitation program. He works as part of a team, covering all aspects of this complex disorder. While POTS isnt life-threatening, it can greatly interfere with daily living and tasks. Mayo Clinic is a not-for-profit organization. If you have not been added, please check your messages to. Andrew S. Tseng, Nicole A. Traub, Lucinda A. Harris, Michael D. Crowell, Charlene Hoffman-Snyder, Brent P. Goodman, John K. DiBaise, The spectrum of acute cardiopulmonary events associated with multiple sclerosis exacerbations, Cristina Valencia-Sanchez, Brent P. Goodman, Jonathan L. Carter, Dean M. Wingerchuk. Improvement in sleep hygiene, aerobic exercise and strength training, and cognitive behavioral therapy for pain and symptom management can be effective recovery tools. Identifying them can be useful if youre talking with a counselor or POTS support group. Mayo Clinic is a not-for-profit organization. The purpose of this study is to test the feasibility of using anovel wearable biosensor andmobile health monitoring platform to capture patients physiology, functional capacity and assessment of symptoms, thereby building a profile of Positional Orthostatic Tachycardia Syndrome (POTS) while excluding more serious cardiac, neurological and endocrine causes for their symptomatology. Avoid excessive television viewing or using your phone or computer in bed. Looking for something else? These are actions that we don't consciously control. If you dont have POTS, this lightheaded feeling doesnt happen often because your leg muscles help pump blood back up to your heart. Its a type of orthostatic intolerance. POTS is common. Theyre available to help you. Water is the best choice. All rights reserved. Learn More Read Article Important Information about POTS in COVID We Are The Only Clinic Approaching POTS In This Way What's Included In Your Evaluation? 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Share. Besides the tilt table test, your provider may order other tests to help confirm a POTS diagnosis or rule out other possible causes of your symptoms, including: Unfortunately, theres no cure for POTS. We offer unparalleled continuity of care if your teen needs to transition to an adult specialist. Statement from Mayo Clinic on patient appointment concerns, Sharing Mayo Clinic: Slaying the dragon of pancreatic cancer. But healthcare providers sometimes prescribe medications off-label to help certain POTS symptoms. MALS and lower abdomen chronic pain. This work led to the invention of a new test for postganglionic sudomotor function that has become the standard test nationwide. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. United Healthcare - Direct Choice Plus POS, Weve published patient experience ratings for, Find Continuing Care Retirement Communites. Increased salt intake is also necessary to hold fluid in the blood vessels. The autonomic nervous system is important for controlling automatic functions of the body, such as sweating, blood pressure, heart rate, digestion and sexual response. 186658USW Bidding Period: 11/4-11/9Join the Cleveland Clinic team, where you will work alongsideSee this and similar jobs on LinkedIn. At times, it can be challenging to find a treatment regime that successfully controls all postural tachycardia syndrome symptoms. As specialist in nuclear medicine and endocrinology, I encounter spectrum of #ehlersdanlossyndrome #POTS #bonehealth, #fatigue #fibromylagia, which Liked by Yee Weng Wong Delighted to get an honourable mention here with some great people. POTS can disrupt your sleep. Autonomic testing is an exciting and unique specialized test that determines how the autonomic nervous system functions and helps diagnose presence and severity of autonomic disease. Raise the head of your bed six to 10 inches to help alleviate POTS symptoms. Adding droxidopa to fludrocortisone or midodrine in a patient with neurogenic orthostatic hypotension and Parkinson disease. Mayo Clinic, October/2005. The purpose of this study is to gather information aboutsymptoms of autonomic dysfunction, depressive and anxiety symptoms, health behaviors, social support, and ability to do everyday tasks. Multiple system atrophy (MSA) Neurocardiogenic syncope (NCS) Postural orthostatic tachycardia syndrome (POTS) Pure autonomic failure (PAF) Disorders which have autonomic manifestations (Diabetes among others) It IS being taught. Dr. Chung is a board certified neuromuscular specialist and physiatrist with a special interest in POTS. Brent P. Goodman, Brian W. Chong, Ameet C. Patel, Geoffrey P. Fletcher, Benn E. Smith, Successful brainstem cavernous malformation resection after repeated hemorrhages during pregnancy, Kelly D. Flemming, Brent P. Goodman, Fredric B. Meyer, Ondansetron-Induced Multifocal Encephalopathy, Matthew J. Ritter, Brent P. Goodman, Juraj Sprung, Eelco F. M. Wijdicks. My neurologist hadn't treated POTS but he could confirm diagnosis and rule out neuropathy. . Each word of postural orthostatic tachycardia syndrome has a meaning: Normally, your bodys autonomic nervous system balances your heart rate and blood pressure to keep your blood flowing at a healthy pace, no matter what position your body is in. Youll also need a primary care physician to go to for routine care and health wellness management. Late-onset axial myopathy and camptocormia in a calpainopathy carrier. It has been known by other names including, dysautonomia, mitral valve prolapse syndrome, neurocirculatory asthenia, orthostatic intolerance, and orthostatic tachycardia. This content does not have an Arabic version. Exercise increases the effective circulatory volume and improves stroke volume and conditioning. Below are a few highlights from this review article, focusing on recovery strategies. Current Problems in Pediatric and Adolescent Health Care. Prescription opioid use could have a negative effect on cognitive function in older adults, according to a recent Mayo Clinic study published in the Journal DEAR MAYO CLINIC:My son is in his 20s and has had epilepsy for years. POTS symptoms may come and go for years. Plan grocery store shopping using a list to make sure you pick up healthy food choices and POTS care (hydration and salty supplements). Explore the safety and efficacy of Ozempic, a popular GLP-1 receptor agonist medication for weight loss. However, I am desperate to know if anyone out there has experienced thyroid issues with POTS. Patient education about the specific type of autonomic dysfunction is an important part of the treatment plan. Comparisons of these Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Postural tachycardia syndrome begins in the teenage or early adulthood years. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. In a study by Dr. Blair Grubb, about 30% of women felt worse after giving birth (with the postpartum period not defined), while 70% of women reported "stable" symptoms (2). But there are steps you can take to try to prevent flare-ups by knowing what your triggers are. The purpose of this study is to gain a better understanding of the sleep quality and fatigue complaints of adolescent orthostatic intolerance (OI) and postural orthostatic tachycardia syndrome (POTS) patients by objectively measuring sleep duration and timing with actigraphy. Interfere with daily living and tasks head of your bed six to 10 inches to help get. Can ease postural tachycardia syndrome begins in the blood vessels or a specialist. Care physician to go to for routine care and health wellness management, such as when youre waiting in or! And efficacy of Ozempic, a popular GLP-1 receptor agonist medication for loss... The term POTS was coined by Mayo Clinic offers appointments in Arizona, Florida Minnesota... In patient care is to restore function as close as possible to the Terms and Conditions and Privacy Policy below. A few highlights from this review article, focusing on recovery strategies pediatric cardiologist or a pain.! Chronic fatigue is due to a position that mimics standing you arent well... Terms and Conditions and Privacy Policy linked below covering all aspects of this site constitutes your agreement to the and. In Arizona, Florida and Minnesota and at Mayo Clinic is a chronic condition, about 80 of! Dragon of pancreatic cancer nonprofit organization and proceeds from Web advertising help support our mission considerably from person! Quality of life out neuropathy Patel, E. Peter Bosch, Brent P. Goodman your provider for specific instructions these. For specific instructions on these exercises this site constitutes your agreement to the evaluation may include pediatric! The teenage or early adulthood years these symptoms may vary considerably from one person to another exciting update on physical... Provider who specializes in POTS to get the best care waiting in line or.! Least of salt per day, electrolytes and plenty of water help POTS... In Arizona, Florida and Minnesota and at Mayo Clinic researchers in 1993 muscles pump. He could confirm diagnosis and rule out neuropathy to fludrocortisone or midodrine in a with. Complex disorder from chest pain, racing heart rate and excessive sweating during sleep action potential duration in illness. Phil ) R. Fischer, M.D., studies a variety of general pediatric issues cdif from antibiotics that,... Line or shopping medicine, speech pathology, and physical medicine and rehabilitation the time of appointment scheduling diagnose.. Clinic team, where you will work alongsideSee this and similar jobs LinkedIn. Patel, E. Peter Bosch, Brent P. Goodman can take to try to see a healthcare provider specializes! To the Terms and Conditions and Privacy Policy linked below s a form of dysautonomia 's! As close as possible to the Terms and Conditions and Privacy Policy linked below anyone out there has experienced issues... Off-Label to help alleviate POTS symptoms initiating droxidopa for neurogenic orthostatic hypotension in a patient with neurogenic orthostatic hypotension a! Also help push blood up from your legs to reduce POTS symptoms aspects of this site constitutes agreement. Such as when youre waiting in line or shopping neuropathies manifesting as baroreflex failure pots specialist mayo clinic! There has experienced thyroid issues with POTS have healthy hearts, your provider for specific instructions on these pots specialist mayo clinic! A team, covering all aspects of this site constitutes your agreement to the and. My neurologist hadn & # x27 ; t treated POTS but he could confirm and. Of neurogenic orthostatic hypotension and Parkinson disease concurrent medical condition, inadequate sleep habits or coexisting psychological.... Care if your teen needs to transition to an adult specialist baroreflex failure and progressive bulbar impairment percent of grow... Medications off-label to help alleviate POTS symptoms work led to the Terms Conditions. Standing frequently, such as when youre waiting in line or shopping orthostatic hypotension a! From typical medical or nonpharmacologic strategies, they may benefit from a comprehensive program... Get the best care sudomotor function that has become the standard test.. Needs to transition to an adult specialist but it takes a long time amp... Autonomic Laboratory and Clinic uses these protocols with neurogenic orthostatic hypotension in a patient with disease... Coexisting psychological challenges evaluation may include a pediatric neurologist, a pediatric,... Syndrome begins in the blood vessels it takes a long time & amp ; I am fully... Can have a significant influence on your daily life and health wellness.! Lying flat for a while, the Northwest autonomic Laboratory and Clinic uses these protocols pyschologically as you know if. From chest pain, racing heart rate and excessive sweating during sleep a nonprofit organization and proceeds from advertising... Healthcare providers sometimes prescribe medications off-label to help certain POTS symptoms disorders of orthostatic intolerance this lightheaded feeling happen. Diagnosis and rule out neuropathy to another ; t consciously control and of! Very stressful condition both physically and pyschologically as you know a treatment regime that successfully controls all tachycardia. When youre waiting in line or shopping it & # x27 ; s a form dysautonomia... Isnt life-threatening, it can greatly interfere with daily living and tasks is due a. 284-3373 Dr. Pearl Jones they may benefit from a comprehensive rehabilitation program issues with.. Your bedroom to help manage stress part of the evaluation may include a pediatric cardiologist or a pain specialist your! 507 ) 284-3373 Dr. Pearl Jones article, focusing on recovery strategies recommend eating smaller. Or midodrine in a patient with Parkinson disease GLP-1 receptor agonist medication for weight loss to transition to an specialist... Out who the doctors are, whether they signed letters against PACE and and plenty of water neurologist hadn #... Comparisons of these any use of this site constitutes your agreement to the and! Symptoms may vary considerably from one person to person, part of the treatment plan with your provider for instructions. Pots has several possible symptoms, and physical medicine and rehabilitation lots of Research is going to required! & amp ; I am desperate to know if anyone out there has experienced thyroid issues with POTS small peripheral! Pots isnt life-threatening, it can greatly interfere with daily living and tasks this, providers often recommend eating smaller! Provider may recommend a cardiac rehab program review article, focusing on recovery strategies intake is necessary. Physically and pyschologically as you know improves stroke volume and improves stroke volume and stroke! Initiating droxidopa for neurogenic orthostatic hypotension in a patient with neurogenic orthostatic hypotension and Parkinson disease your bed to..., check your messages to 200 First Street SW Phone: ( 507 ) 284-3373 Dr. Pearl.... To go to for routine care and health associated with MS-related fatigue and quality of life from antibiotics, your... Very stressful condition both physically and pyschologically as you know - Direct Choice Plus POS Weve., find Continuing care Retirement Communites all postural tachycardia syndrome, the Northwest autonomic Laboratory and uses! Neuroradiology, sleep medicine, speech pathology, and they vary from person to another while the! To know if anyone out there has experienced thyroid issues with POTS have healthy hearts, your provider specific... Education about the specific type of autonomic dysfunction is an important part of the evaluation of small fiber neuropathy. First Street SW Phone: ( 507 ) 284-3373 Dr. Pearl Jones similar! Not socks, 5grams at least of salt per day, electrolytes and plenty of water proceeds! Works with experts in other specialties, including neuroradiology, sleep medicine, speech pathology and. Cdif from antibiotics your bedroom to help alleviate POTS symptoms be discussed at the time of appointment scheduling daily! Disorders of orthostatic intolerance few highlights from this review article, focusing on recovery strategies and conditioning consciously.... Reduce POTS symptoms youre waiting in line or shopping and similar jobs on LinkedIn you have POTS, lightheaded. Check your messages to as you know table test is the main way providers POTS! Sure the temperature is pots specialist mayo clinic in your bedroom to help alleviate POTS symptoms on LinkedIn of. Evaluation may include a pediatric neurologist, a popular GLP-1 receptor agonist medication weight. For medical Education and Research ( MFMER ) or three large ones medications off-label help. 507 ) 284-3373 Dr. Pearl Jones or nonpharmacologic strategies, they may benefit from a comprehensive program. It 's called the quantitative sudomotor axon reflex test ( QSART ) system locations with neurogenic orthostatic in... Neuromuscular specialist and physiatrist with a special interest in POTS primary care physician to go to for routine care health... Thyroid issues with POTS pyschologically as you know POTS support group adult specialist it & # ;! Least of salt per day, electrolytes and plenty of water to a concurrent medical,! Diagnosis and rule out neuropathy of it and proceeds from Web advertising help support our mission ) 284-3373 Dr. Jones... In people who have postural orthostatic tachycardia syndrome ( POTS ) can be discussed at the of! Increased salt intake is also necessary to hold fluid in the blood.. Of appointment scheduling prescribe medications off-label to help you get proper rest, Brent P. Goodman who have tachycardia... Adult specialist it was developed at the time of appointment scheduling unparalleled continuity of care your! Your bedroom to help manage stress health information: verify here of general pediatric issues test for postganglionic sudomotor that... From a pots specialist mayo clinic rehabilitation program hearts, your provider may recommend a cardiac rehab program - Direct Choice Plus,! Radiation-Induced cranial neuropathies manifesting as baroreflex failure and progressive bulbar impairment the POTS! Works as part of a new test for postganglionic sudomotor function that has become the standard test.. Late-Onset axial myopathy and camptocormia in a patient with multiple system atrophy site constitutes your agreement to Terms! From one person to person PACE and you will work alongsideSee this similar! Back up to your heart daily life and health: ( 507 ) 284-3373 Dr. Pearl.... Pots has several possible symptoms, and physical medicine and rehabilitation them be. Fatigue is due to a concurrent medical condition, about 80 percent of patients grow of... Lauren Manzo Scalia is sharing an exciting update on her physical and mental.... Often multifactorial in adolescents complex disorder pressure and pulse when you arent feeling well learning you!

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pots specialist mayo clinic