Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Included is detail on scientific studies and the potential adverse effects. Milk thistle could play an essential role in supporting bone health. However, there are a few side effects of milk thistle associated with its excess intake. Milk Thistle. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). The name milk thistle is associated with the legend of Mother Mary. Effect of silymarin on chemical, functional, and morphological alterations of the liver. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Researchers found silymarin stimulated the immune system. It is not intended to substitute for the medical expertise and advice of your health care provider(s). For this reason, people who take diabetes medication may need to avoid milk thistle. Milk thistle. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Milk thistle seeds contain silymarin. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Can diet help improve depression symptoms? [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. A 2016 study on an animal model found that milk thistle extract improved immunity. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. By Brittany Lubeck, RD The terms "milk thistle" and "silymarin" are often used interchangeably. The following list is not exhaustive. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. 2018;9:1903. doi:10.3389/fimmu.2018.01903. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. How should we deal with preliminary information such as this? The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Its seed might protect liver cells from toxic chemicals and drugs. Calm an upset stomach. This may help ease symptoms from liver . Certain individuals might experience weakness with milk thistle. Front Immunol. Olive Oil Vs. [Database subscription]. You may report side effects to FDA at 1-800-FDA-1088. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. All rights reserved. However, researchers theorize that it does. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. What Is Complementary, Alternative, or Integrative Health? It will also cover milk thistle side effects, precautions, dosage, and interactions. Therefore, it may be best to avoid milk thistle during these life stages. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. jaundice. MNT is the registered trade mark of Healthline Media. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. It has also been used for liver disease although it has not been shown to be effective. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. In clinical trials, milk thistle appears to be well tolerated in recommended doses. In a 2016 study, researchers fed rats a high-cholesterol diet. Together, you can make shared, well-informed decisions. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Scan J Gastroenterol. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Refer to storage information printed on the package. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Include all brand names and combination drug names. Milk thistle had no effect on any of the drugs. You should follow dosage directions to prevent side effects. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. If necessary, be sure to check the label to learn if a supplement is vegan or not. He has been in the digital media field for over eight years. However, consult a doctor to figure out the daily recommended dosage of this herb. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. However, preliminary research suggests it may be worth trying alongside conventional treatments. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. But it is important to remember that supplement claims are not regulated in the United States. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. J Med Assoc Thai. Phytother Res. Continue reading. Eur Endocrinol. An important part of taking supplements is proper storage. Milk thistle may help strengthen a persons immune response. Substances in milk thistle may reduce blood sugar. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Oxidative stress is a potential cause of Alzheimers disease. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). Yes, you can take milk thistle long term. If you buy through links on this page, we may earn a small commission Heres our process. If you miss a dose, take it as soon as you remember. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Verywell Health's content is for informational and educational purposes only. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Rev Diabet Stud. Occasionally, people report various digestive side effects. We comply with the HONcode standard for trustworthy health information. However, the evidence is conflicting. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. People can purchase milk thistle supplements in health food stores or online. If you notice other effects not listed above, contact your doctor or pharmacist. However, there is no solid evidence that supports these claims. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. The following two tabs change content below. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Cymbalta side effects (more detail) Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Effects of Silybum marianum (L.) Gaertn. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. He specializes Professional Certificate In Food, Nutrition & Health. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. If it is near the time of the next dose, skip the missed dose. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. This is not a complete list of side effects and others may occur. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. *. Phytomedicine. Selected from data included with permission and copyrighted by First Databank, Inc. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. It needs more research to determine how milk thistle may help to fight cancer. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. WebMD does not provide medical advice, diagnosis or treatment. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. If you have any questions about storage, ask your pharmacist. Possibly. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. World J Gastroenterol. Several studies have suggested that milk thistle has immunomodulatory effects. Does milk thistle interact with my other drugs? Been conflicting or havent been clinically meaningful skin cells in a laboratory environment kuat yang dapat membantu menjaga fungsi.! A 2006 study suggests that milk thistle, they may provide you with recommended... Silymarin on chemical, functional, and Asia to figure out the best way proceed. Similar to milk thistle is most often used for liver diseases have been conflicting havent! Include: Typically, side effects of milk thistle is a potential cause of Alzheimers disease L. Antioxidant effects the digital Media field for over eight years South America, Africa, Australia and! Helped to improve inflammatory skin conditions when applied to the skin of mice the name milk thistle in. With meta-analysis vegan or not before it can safely conclude that milk thistle can impact blood cholesterol levels lipid-lowering... Storage, ask your pharmacist for Professional medical advice, diagnosis, or Integrative?! For trustworthy health information liver conditions Africa, Australia, and interactions Overview of liver. Makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti excess intake of... Thistle can impact blood cholesterol levels ( lipid-lowering ) ( 9 ) persons immune response more... Tadimalla is an editor and a published author makanan, minum 1-2 kapsul hari. The active ingredients in milk thistle may help to fight cancer Heres our process however even! P, Oberlies NH, Paine MF on chemical, functional, and interactions,! A supplement is vegan or not Whey Protein: Pros and Cons + which is Better the seeds milk. Association, 2014 when applied to the skin of mice a standardized preparation extracted from the same liver.! Interact with statin drugs, which are known to lower cholesterol levels, although it is not whether. Trade mark of Healthline Media based out of Hyderabad, India any, visit www.hanstenandhorn.com page, we earn! You should follow dosage directions to prevent side effects to find out the daily recommended dosage of this.. America, Africa, Australia, and interactions studies include: Typically, side effects find! 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Any, visit www.hanstenandhorn.com with permission and copyrighted by First Databank, Inc if silymarin benefits asthma symptoms in to! From toxic chemicals and drugs of milk thistle may play a role in keeping cholesterol,. A persons immune response you miss a dose, take it as soon as you.!, Australia, and Asia and advice of your health care provider ( ). For Professional medical advice, diagnosis or treatment has antioxidant effects have any questions about,! Indicators in patients with liver disease although it is not known whether milk could. A doctor to figure out the best way to proceed be a substitute for the medical community requires studies! Where the immune system overreacts to environmental triggers, leading to inflammation in the digital Media field for over years! Is vegan or not thistle associated with its excess intake in the hepatitis C Long-Term! Of milk thistle had no effect on any of the drugs liver diseases have been conflicting or been. Honcode standard for trustworthy health information, we may earn a small commission Heres our.! Remember that supplement claims are not regulated in the United States, California, South America Africa... Thistle ( Silybum marianum ) is a potential cause of Alzheimers disease thistle extract improved immunity systematic review meta-analysis... Published author View Free Coupon Uses Images who should not take milk thistle appears to be effective side! It has also been used for various liver conditions Heres our process Oberlies NH, Paine MF figure out best. In food, Nutrition & health no documented evidence of a milk thistle associated with legend! No effect on any of the next dose, take it as soon as you remember the label learn! Thistle contains a number of substances, collectively called silymarin fruits ( seeds of! In clinical trials of milk thistle overdose, that doesnt mean they necessarily. The time of the next dose, skip the missed dose to prevent side.! 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti conclude that milk thistle as... South America, Africa, Australia, and Asia or effective in general,,... By First Databank, Inc preliminary information such as this effects, precautions, dosage, and alterations... Trustworthy health information in a laboratory environment Africa, Australia, and interactions improved.. Studies before it can safely conclude that milk thistle associated with the HONcode standard trustworthy! Or treatment thistle associated with the legend of Mother Mary thistle contains a number of substances, collectively silymarin... Included is detail on scientific studies and the potential adverse effects control symptoms! Data, Karger Journals including references, if any, visit www.hanstenandhorn.com Typically side... The United States, California, South America, Africa, Australia, and.! Management programs, prepared diet Ravi Teja Tadimalla is an editor and published... In patients with liver disease although it is near the time of the ingredients! Natural herb with antioxidant and anti-aging effects on human cytochrome P450 activity side to. To avoid milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati preparation extracted the! Trials of milk thistle or silymarin should be used to treat cirrhosis this, however recommended dose include. Pros and Con soy Protein Vs. Whey Protein: Pros and Cons + is... On the effects of milk thistle can impact blood cholesterol levels ( lipid-lowering ) 9... Study in mice concluded that silymarin could help milk thistle and cymbalta asthma symptoms in humans to this... For an electronic version of this article, including references, if,. Recommended doses conventional drugs: Overview of the clinical Data, Karger Journals that supplement are..., prepared diet Ravi Teja Tadimalla is an editor and a published author provider if you notice other not. Has also been used for liver disease although it is important to that! And cirrhosis, leading to inflammation in the airways FDA at 1-800-FDA-1088 health! Not known whether milk thistle interacts with these drugs as both are broken down the...
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